The neurotrophin receptors TrkA and TrkC but not TrkB cause neuronal death
نویسندگان
چکیده
Biozentrum, University of Basel, CH-4056 Basel, Switzerland; Helmholtz Zentrum München, Institute of Stem Cell Research, Ingolstädter Landstrasse 1, D-85764 Neuherberg, Germany; Instituto Cajal, CSIC, Avda Dr Arce 37, E-28002 Madrid, Spain; Neurodegeneration Department, Neuroscience Research, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland 5 present address: Novartis Pharma AG, Department of Neuroscience/Ophthalmics, Clinical Development & Medical Affairs CH-4051 Basel
منابع مشابه
Characterization of Neurotrophin and Trk Receptor Functions in Developing Sensory Ganglia Direct NT-3 Activation of TrkB Neurons In Vivo
Spinal sensory ganglia have been shown to contain neuronal subpopulations with different functions and neurotrophin dependencies. Neurotrophins act, in large part, through Trk receptor tyrosine kinases: nerve growth factor (NGF) via TrkA, brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT-4/5) via TrkB, and neurotrophin-3 (NT-3) via TrkC. In the present paper, we use antibodies t...
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Animals lacking neurotrophin-3 (NT-3) are born with deficits in almost all sensory ganglia. Among these, the trigeminal ganglion is missing 70% of the normal number of neurons, a deficit which develops during the major period of neurogenesis between embryonic stages (E) 10.5 and E13.5. In order to identify the mechanisms for this deficit, we used antisera specific for TrkA, TrkB, and TrkC to ch...
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In terrestrial vertebrates such as birds and mammals, neurotrophin receptor expression is considered fundamental for the specification of distinct somatosensory neuron types where TrkA, TrkB and TrkC specify nociceptors, mechanoceptors and proprioceptors/mechanoceptors, respectively. In turn, Runx transcription factors promote neuronal fate specification by regulating neurotrophin receptor and ...
متن کاملNeurotrophin Trk receptors in the brain of a teleost fish, Nothobranchius furzeri.
Trk neurotrophin receptors are transmembrane tyrosine kinase proteins known as TrkA, TrkB, and TrkC. TrkA is the high affinity receptor for nerve growth factor, TrkB is the one for both brain-derived neurotrophic factor and neurotrophin-4, and TrkC is the preferred receptor for neurotrophin-3. In the adult mammalian brain, neurotrophins are important regulators of neuronal function and plastici...
متن کاملExpression of functional TrkA receptor tyrosine kinase in the HMC-1 human mast cell line and in human mast cells.
Nerve growth factor (NGF) can influence mast cell development and function in murine rodents by interacting with its receptors on mast cells. We now report the identification of mRNA transcripts of full-length tyrosine kinase-containing trkA, trkB, and trkC neurotrophin receptor genes in HMC-1 human mast cell leukemia cells. Although HMC-1 cells lacked p75 mRNA, they expressed transcripts for t...
متن کاملPresence and localization of neurotrophins and neurotrophin receptors in rat lacrimal gland.
PURPOSE To determine which of the neurotrophins (NTs)-nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT3), and neurotrophin-4/5 (NT4)-and their receptors (NTrs), TrkA, TrkB, TrkC, and p75, are present in the adult rat lacrimal gland. METHODS RT-PCR was performed on RNA isolated from male rat lacrimal gland, using oligonucleotides specific to each NT and N...
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